Fig. 8
From: ALKBH5 modulates macrophages polarization in tumor microenvironment of ovarian cancer
ALKHB5 promoted M2 macrophage polarization in ovarian cancer. A Differential expression of ALKBH5 in normal ovary and ovarian cancer immune cells. B Overexpression of ALKBH5 in macrophages inhibited TNF-α expression and promoted IL-10, ARG-1 expression. C Inhibition of ALKBH5 in macrophages promoted CD86 expression and inhibited CD163, CCL22 expression. D Correlation between ALBKH5 and immune inhibitors in ovarian cancer. E Correlation between ALBKH5 and macrophages polarization markers in ovarian cancer. F PPI network constructed according to the DEGs of ALKBH5 in ovarian cancer using cytoscape. G Bubble plots showed GO and KEGG analysis of DEGs based on TCGA. H Circos plots showed the GO and KEGG analysis of DEGs based on TCGA